Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 8314
Gene Symbol: BAP1
BAP1
0.100 Biomarker disease BEFREE Our observations reveal a potential clinical application where BAP1 status could serve as predictive or stratification biomarker for RNR inhibition-based therapy in MPM. 31619462 2020
Entrez Id: 10232
Gene Symbol: MSLN
MSLN
0.100 AlteredExpression disease BEFREE In contrast, effusion SMRP levels were exclusively high in epithelioid MPM, negatively correlated with effusion TGF-β levels and did not provide prognostic information. 31778960 2020
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.100 Biomarker disease BEFREE MTAP immunohistochemistry is an accurate and reproducible surrogate for CDKN2A fluorescence in situ hybridization in diagnosis of malignant pleural mesothelioma. 31231127 2020
Entrez Id: 8314
Gene Symbol: BAP1
BAP1
0.100 AlteredExpression disease BEFREE We used FISH to examine deletion status of NF2 and 9p21 and immunohistochemistry to examine expression of MTAP and BAP1 in malignant pleural mesothelioma and in reactive mesothelial hyperplasia. 31231129 2020
Entrez Id: 4507
Gene Symbol: MTAP
MTAP
0.080 Biomarker disease BEFREE MTAP immunohistochemistry is an accurate and reproducible surrogate for CDKN2A fluorescence in situ hybridization in diagnosis of malignant pleural mesothelioma. 31231127 2020
Entrez Id: 4507
Gene Symbol: MTAP
MTAP
0.080 AlteredExpression disease BEFREE We used FISH to examine deletion status of NF2 and 9p21 and immunohistochemistry to examine expression of MTAP and BAP1 in malignant pleural mesothelioma and in reactive mesothelial hyperplasia. 31231129 2020
Entrez Id: 10413
Gene Symbol: YAP1
YAP1
0.060 AlteredExpression disease BEFREE Inhibition of CDK7 by siRNA decreased the YAP protein level and the GTIIC reporter activity in the MPM cell lines 211H, H290 and H2052. 31755214 2020
Entrez Id: 4771
Gene Symbol: NF2
NF2
0.030 GeneticVariation disease BEFREE However, the application of FISH detection of NF2 gene deletion (NF2 FISH) in differentiation of malignant pleural mesothelioma from reactive mesothelial hyperplasia has not been fully evaluated. 31231129 2020
Entrez Id: 1493
Gene Symbol: CTLA4
CTLA4
0.030 AlteredExpression disease BEFREE Since most malignant pleural mesotheliomas do not respond to anti-programmed cell death(-ligand)1 (PD-(L)1)/cytotoxic T-lymphocyte-associated protein 4 (CTLA4) therapy and given the recent finding of The Cancer Genome Atlas Study that pleural mesothelioma displays the highest expression of VISTA among all cancers studied, we examined VISTA expression in a large pleural mesothelioma cohort. 31537897 2020
Entrez Id: 50943
Gene Symbol: FOXP3
FOXP3
0.020 AlteredExpression disease BEFREE In this study, 172 well-characterised primary diffuse MPM tumours including epithelioid (n = 145), biphasic (n = 15), and sarcomatoid (n = 12) histotypes were evaluated immunohistochemically for CD70, CD27, CD3, CD4, CD8, CD56, PDCD1 (PD-1), and FOXP3 expression. 31639216 2020
Entrez Id: 1022
Gene Symbol: CDK7
CDK7
0.010 AlteredExpression disease BEFREE Inhibition of CDK7 by siRNA decreased the YAP protein level and the GTIIC reporter activity in the MPM cell lines 211H, H290 and H2052. 31755214 2020
Entrez Id: 340273
Gene Symbol: ABCB5
ABCB5
0.010 Biomarker disease BEFREE ABCB5 may represent a new target to chemosensitize MPM IC and a potential biomarker to predict the response to the first-line chemotherapy in MPM patients. 31107974 2020
Entrez Id: 939
Gene Symbol: CD27
CD27
0.010 Biomarker disease BEFREE Collectively, these findings suggest that the CD70-CD27 pathway enhances the malignant phenotypes of MPM and diminishes anti-tumor immune response in patients with these neoplasms. 31639216 2020
Entrez Id: 970
Gene Symbol: CD70
CD70
0.010 GeneticVariation disease BEFREE In this study, 172 well-characterised primary diffuse MPM tumours including epithelioid (n = 145), biphasic (n = 15), and sarcomatoid (n = 12) histotypes were evaluated immunohistochemically for CD70, CD27, CD3, CD4, CD8, CD56, PDCD1 (PD-1), and FOXP3 expression. 31639216 2020
Entrez Id: 7465
Gene Symbol: WEE1
WEE1
0.010 Biomarker disease BEFREE We further showed that deregulation of the G2-M checkpoint contributes to chemotherapy resistance, and that WEE1 inhibition synergizes with cisplatin/MTA, leading to enhanced MPM cell death in vitro and potent anti-tumor effects in vivo. 31694888 2020
Entrez Id: 10232
Gene Symbol: MSLN
MSLN
0.100 Biomarker disease BEFREE Diagnostic value of soluble mesothelin-related peptides in pleural effusion for malignant pleural mesothelioma: An updated meta-analysis. 30946324 2019
Entrez Id: 8314
Gene Symbol: BAP1
BAP1
0.100 Biomarker disease BEFREE Identification of BRCA1-associated protein 1 (BAP1) and cyclin-dependent kinase inhibitor 2A (CDKN2A) gene mutations in MPM have led to the development of new ancillary tests that can streamline the diagnostic pathway. 31169558 2019
Entrez Id: 8314
Gene Symbol: BAP1
BAP1
0.100 AlteredExpression disease BEFREE We examined IHC expression of EZH2, BAP1, and MTAP, and 9p21 FISH in MPM (n = 38) and RMH (n = 29) and analyzed the sensitivity and specificity of each detection assay for distinguishing MPM from RMH. 30885343 2019
Entrez Id: 10232
Gene Symbol: MSLN
MSLN
0.100 Biomarker disease BEFREE Mesothelin, Calretinin, and Megakaryocyte Potentiating Factor as Biomarkers of Malignant Pleural Mesothelioma. 31267149 2019
Entrez Id: 4233
Gene Symbol: MET
MET
0.100 Biomarker disease BEFREE MET PET is able to characterize MPM lesions regardless of histology. 31568271 2019
Entrez Id: 10232
Gene Symbol: MSLN
MSLN
0.100 Biomarker disease BEFREE Correction: MSLN gene silencing has an anti-malignant effect on cell lines overexpressing mesothelin deriving from malignant pleural mesothelioma. 28640856 2019
Entrez Id: 10232
Gene Symbol: MSLN
MSLN
0.100 Biomarker disease BEFREE Unresectable MPM has a poor prognosis and limited treatment options and, as such, there is a broad range of therapeutic targets of interest, including angiogenesis, immune checkpoints, mesothelin, as well as chemotherapeutic agents. 31280996 2019
Entrez Id: 8314
Gene Symbol: BAP1
BAP1
0.100 GeneticVariation disease BEFREE The top hypomethylated single-CpG (cases versus controls effect size less than -0.15, p<sub>fdr</sub> < 0.05 in both the training and test sets) was detected in FOXK1 (Forkhead-box K1) gene, an interactor of BAP1 which was found mutated in MPM tissue and as germline mutation in familial MPM. 30408567 2019
Entrez Id: 10232
Gene Symbol: MSLN
MSLN
0.100 AlteredExpression disease BEFREE CRS-207 is a live-attenuated <i>Listeria monocytogenes</i> engineered to express mesothelin, a tumor-associated antigen highly expressed in MPM. 31263030 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.100 AlteredExpression disease BEFREE Additionally, we have seen higher EGFR expression associating with worse outcomes after Photofrin-mediated PDT for MPM, and the extensive desmoplastic reaction associated with MPM influences tumor phenotype and therapeutic response. 30499112 2019